Luis De Jesus Los Angeles is a contemporary art gallery representing emerging and mid-career artists who are engaged in regional and global art discourse with a particular focus on intersectional diversity. These artists use conceptual and formal strategies as a critical lens to address a myriad of concerns including the social constructs of gender, racial, and subjective identity, the power of aesthetic frameworks to shape political and economic reality, and the historical role of the artist within society. Gallery artists are exhibited regularly in international institutions and biennials.

Luis De Jesus Los Angeles opened in Santa Monica's Bergamot Station in 2010 and relocated to the Culver City Arts District in 2011 where the gallery operated for ten years.  In 2021, the gallery opened an expansive space in the downtown Los Angeles Arts District.  Prior to moving to Los Angeles, owners Luis De Jesus and Jay Wingate opened their first gallery in San Diego in 2007 known as Seminal Projects.